Headline : Study uncovers a unique, efficient method of copper delivery in cells

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A new study has uncovered a unique way in which the anti-cancer drug elesclomol enables copper delivery in cells, aiding in the search for treatments for copper deficiency disorders such as Menkes disease.

Menkes disease is an extremely rare hereditary copper-deficiency disorder in infants. It is characterized by progressive neurological injury culminating in death, typically by the age of three.

A Texas A&M AgriLife Research team led by Vishal Gohil, Ph.D., associate professor in the Department of Biochemistry and Biophysics in Texas A&M’s College of Agriculture and Life Sciences, Bryan-College Station, first discovered the therapeutic potential of elesclomol for treating copper deficiency disorders. Additionally, previous research by Gohil’s team showed that elesclomol could be used effectively in a mouse model to treat Menkes disease.

The new study, “FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery,” was recently published in the Proceedings of the National Academy of Sciences, a peer-reviewed journal of the National Academy of Sciences. The research was led by Gohil, with Mohammed Zulkifli, Ph.D., a research scientist in the same department, as the first author of the study. 

Read more from the original article on here at agrilifetoday.tamu.edu.

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