Headline : Endurance exercise affects all tissues of the body, even those not normally associated with movement

Read more from the original article on here at www.nih.gov.

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NIH-funded project in rats also finds widespread differences between male and female organisms.

A large research project in young adult rats has found that that all bodily tissues tested respond to exercise training, amounting to over 35,000 biological molecules that respond and adapt to endurance exercise over time, including tissues from organs not usually associated with exercise. Researchers also found differences in responses between male and female rats that were more widespread than anticipated, highlighting the importance of including animals of both sexes in pre-clinical research. The effort, funded by the National Institutes of Health (NIH), used data from thousands of analyses of 19 tissue types and identified molecular changes in genes, proteins, and metabolites, which are substances essential to the metabolism of a particular organism or to a particular metabolic process. The findings are published in a group of papers in Nature.

While molecular changes were seen in all tissues, the way in which each tissue responded was unique. For example, effects on the functions of mitochondria, which are cellular hubs for energy production and metabolism, were observed across the body yet the specific changes observed differed depending on the tissue. For example, researchers found that mitochondria in the adrenal gland responded substantially to endurance training, including a change in regulation of nearly half the mitochondria-associated genes. This was surprising as adrenal glands had not been explored in detail for their role in exercise previously.

Additionally, differences were found in molecular responses to endurance exercise between young male and female rats in most tissues tested, including the brain, adrenal gland, lung, and fat tissue. Scientists uncovered striking differences in responses between the sexes in white fat tissue, findings that may play a role in researching how exercise interventions could be recommended for men or women experiencing conditions such as obesity. The differences between the exercise responses of the sexes in humans or animals have not been well characterized, and these findings emphasize the need for inclusion of both sexes in future exercise research to fully understand its role in health.

Read more from the original article on here at www.nih.gov.

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